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CDK2 — EPHB2

Text-mined interactions from Literome

Keenan et al., J Biol Chem 2001 : Here, we show that ERK also affects CDK2-cyclin E activation by regulating the subcellular localization of CDK2
Lents et al., J Biol Chem 2002 : Taken together, these data show a new role for ERK in G1 cell cycle progression : In addition to its role in stimulating cyclin D1 expression and nuclear translocation of CDK2 , ERK regulates Thr-160 phosphorylation of CDK2-cyclin E
Alldridge et al., Exp Cell Res 2003 (MAP Kinase Signaling System) : Moreover, ANXA1 reduces proliferation by ERK mediated disruption of the actin cytoskeleton and ablation of cyclin D1 protein expression and not by ERK mediated induction of the cyclin dependent kinase , CDK2, inhibitor p21 ( cip/waf )
Huynh et al., Int J Oncol 2004 (Carcinoma, Hepatocellular...) : Our data indicate that activated ERK plays an important role in cyclin D1 and Cdk-2 expression and phosphorylation of pRB at Ser780 and Ser795 in liver cancer cells
Kobayashi et al., J Biol Chem 2007 : Immunoblotting demonstrated that phosphorylation at this site was maximal in cells in G2/M phase, was enhanced by tumor necrosis factor-alpha related apoptosis inducing ligand ( TRAIL ) treatment, was blocked by inhibitors of CDK ( but not ERK or glycogen-synthase kinase 3beta ), and was stimulated in vitro by CDK 1, CDK2 , and JNK1
Bokemeyer et al., Nephrol Dial Transplant 2007 (Glomerulonephritis) : The map kinase ERK regulates renal activity of cyclin dependent kinase 2 in experimental glomerulonephritis ... In stimulated MC, inhibition of ERK reduced cyclin dependent kinase 2 (CDK2) phosphorylation, CDK2 activity and cyclin E/A expression, whereas downregulation of CDK inhibitor p27 ( Kip1 ) expression was inhibited
Saito et al., J Exp Med 2010 (Cell Transformation, Neoplastic...) : In nonpolarized epithelial cells, Erk activation results in oncogenic stress, up-regulation of the p21 ( Waf1/Cip1 ) cyclin dependent kinase inhibitor, and induction of senescence
Yang et al., Eur J Pharmacol 2011 (Carcinoma, Non-Small-Cell Lung...) : Our findings suggest that the ERK mediated Cdk2/cyclin-A signaling pathway is an important regulator of pemetrexed induced S-phase arrest and apoptotic cell death
Hong et al., Exp Cell Res 2011 (Prostatic Neoplasms) : Ectopic expression of a constitutively active AR inhibited Raf/MEK/ERK mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the cyclin dependent kinase inhibitors, p16(INK4A) and p21 ( CIP1 ), but not Rb phosphorylation and E2F1 expression, indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling