Gene interactions and pathways from curated databases and text-mining

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CDK2 — TCHP

Text-mined interactions from Literome

Costanzo et al., Cell 2004 : In metazoans, CDK dependent phosphorylation of the retinoblastoma tumor suppressor protein ( Rb ) alleviates repression of E2F and thereby activates G1/S transcription
Rego et al., Oncogene 2012 (Fanconi Anemia) : In this study, we have examined the roles of the p53 tumor suppressor protein , as well as its downstream target, the p21 ( Cip1/Waf1 ) cyclin dependent kinase inhibitor , in the regulation of the activation of the FA-BRCA pathway
Day et al., J Biol Chem 1997 : This loss of cyclin dependent kinase activity leads to accumulation of the hypophosphorylated ( active ) form of the retinoblastoma tumor suppressor protein ( Rb )