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LPA — MAP2K1
Text-mined interactions from Literome
Cui et al., Arterioscler Thromb Vasc Biol 2003
:
Phosphorylation of
mitogen activated protein kinase kinase ( MEK ) and extracellular signaling regulated kinases ( ERK1/2 ) was rapidly and markedly
induced by
LPA
Bian et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
In this article, we demonstrate that
LPA activates
mitogen activated protein kinase kinase 1 ( MEKK1 ) in a G ( i ) -Ras dependent manner and that MEKK1 activity is essential for LPA stimulated ovarian cancer cell migration
Cunnick et al., J Biol Chem 1998
:
PD158780 potently inhibited the
LPA stimulated
MAP kinase kinase 1/2 ( MKK1/2 ) activation and EGF receptor tyrosine phosphorylation in HeLa cells, while it had no detectable effect on c-Src kinase activity ... PD158780 also inhibited
LPA induced
MKK1/2 activation and DNA synthesis in NIH 3T3 cells ... Furthermore, we compared
LPA stimulated
MKK1/2 and MAP kinase activation, transcriptional activity of the c-fos promoter, and DNA synthesis in B82L cells, which lack endogenous EGF receptor, and B82L cells expressing kinase-defective or wild-type human EGF receptor