Gene interactions and pathways from curated databases and text-mining

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EPHB1 — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → EPHB1 (increases, EPHB1 Activity, MAPK3 Activity) Vindis et al., J Cell Biol 2003
    Evidence: Here we demonstrate that activated EphB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal-regulated kinase (ERK) activation.

Text-mined interactions from Literome

Yosimichi et al., Eur J Biochem 2001 : These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear activating transcription factor-2 ( Atf-2 ) induced by CTGF/Hcs24 in a dose dependent manner, respectively
Vindis et al., J Cell Biol 2003 : Together these findings highlight a new aspect of EphB1 signaling, whereby the concerted action of c-Src and p52Shc activates MAPK/ERK and regulates events involved in cell motility
Geng et al., Neurochem Int 2013 : Moreover, EphB2 overexpression prevented Aß1-42 oligomer induced downregulation of dephosphorylated p38 MAPK and phosphorylated CREB