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PTK7 — WNT4
Text-mined interactions from Literome
Peradziryi et al., EMBO J 2011
:
PTK7/Otk interacts with Wnts and
inhibits canonical
Wnt signalling ... PTK7/Otk co-precipitates canonical Wnt3a and
Wnt8 , indicating a role in Wnt signalling, but
PTK7 inhibits rather than activates canonical Wnt activity in Xenopus, Drosophila and luciferase reporter assays
Hayes et al., Development 2013
(Wnt Signaling Pathway) :
However, conflicting reports have indicated both positive and negative
roles for
Ptk7 in canonical
Wnt/ß-catenin signalling ... Furthermore, during late gastrula and segmentation stages, we observe significant upregulation of ß-catenin target gene expression and demonstrate a clear
role for
Ptk7 in attenuating canonical
Wnt/ß-catenin activity in vivo