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IFNG — SMAD2

Text-mined interactions from Literome

Sumiyoshi et al., J Dermatol Sci 2003 : TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha induced TARC ( CCL17 ) production in HaCaT cells
Gu et al., Acta Pharmacol Sin 2004 : IFN-gamma 200 microg/L did not block TGF-beta1 stimulated Smad2/3 phosphorylation and their nuclear translocation
Thomas et al., Cancer Cell 2005 : Repression of granzyme B and interferon-gamma involves binding of TGF-beta activated Smad and ATF1 transcription factors to their promoter regions, indicating direct and selective regulation by the TGF-beta/Smad pathway
Tanaka et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental) : TGF-beta mediated Smad transcriptional activity was severely inhibited in SOCS1-deficient cells in the presence of IFN-gamma ... Induction of SOCS3 can partly explain IFN-gamma mediated STAT3 suppression, while other mechanism ( s ) will be involved in IFN-gamma mediated Smad suppression
Takimoto et al., J Immunol 2010 (Inflammation) : In this study, we generated T cell-specific Smad2 conditional knockout ( KO ) mice and unexpectedly found that Smad2 and Smad3 were redundantly essential for TGF-beta mediated induction of Foxp3 expressing regulatory T cells and suppression of IFN-gamma production in CD4 ( + ) T cells