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IL2 — PTHLH
Text-mined interactions from Literome
Ikeda et al., Endocrinology 1993
(Deltaretrovirus Infections...) :
A monoclonal antibody against IL-2 receptor ( anti-Tac antibody ) inhibited the
IL-2 induced increase in
PTHRP mRNA level ... The secretion of
PTHRP , as determined by both a newly established immunoradiometric assay using recombinant human PTHRP ( 1-87 ) as the standard and an RIA using an antibody against PTHRP ( 109-141 ), was
increased by
IL-2 but not by IL-1, IL-3, IL-4, or IL-6 ... The
IL-2 induced increase in
PTHRP secretion was completely inhibited by the addition of anti-Tac antibody ... These results demonstrate that IL-2 stimulates the production and secretion of
PTHRP by HTLV-I infected T cells through specific binding to IL-2 receptor and that the effect of
IL-2 is
mediated by a posttranscriptional as well as a transcriptional mechanism
Casey et al., J Clin Endocrinol Metab 1993
:
17 beta-Estradiol ( E2 ),
interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), endothelin-1 (ET-1), transforming growth factor-beta 1 ( TGF beta 1 ), and serum
stimulated PTH-rP production ( evaluated by immunoassay of PTH-rP in the culture medium ) by these cells
Ikeda et al., J Biol Chem 1993
(Cell Transformation, Viral) :
These results suggest that the transcription of the human PTHRP gene is enhanced through a cAMP dependent pathway by PGE1 and that PGE1, as well as
interleukin 2 ,
plays an important role in the overexpression of the human
PTHRP gene in HTLV-I infected T cells leading to the development of hypercalcemia in ATL patients
Inoue et al., J Biol Chem 1993
:
OCT inhibited not only the basal secretion but also the
stimulation of
PTHRP secretion by
interleukin-2 or cAMP, which we had identified as two important stimulators
Mori et al., Jpn J Cancer Res 1993
(Leukemia, T-Cell) :
To elucidate whether
PTHrP produced by ATL cells is
regulated by
IL-2 or IL-4, we investigated the in vitro effects of IL-2 and IL-4 on the release of PTHrP ...
IL-2 increased the release of PTHrP into the conditioned medium from leukemic cells in some, but not all, ATL patients ; however, IL-4 did not affect the
PTHrP release