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IL12B — IL17D
Text-mined interactions from Literome
Lucas et al., Proc Natl Acad Sci U S A 2003
:
IL-27 regulates
IL-12 responsiveness of naive CD4+ T cells through Stat1 dependent and -independent mechanisms
Rowland et al., Infect Immun 2006
(Glanders) :
IL-12 was essential for IFN-gamma production in vitro ; IL-18 was also involved in induction of IFN-gamma, but
IL-27 was not
required for IFN-gamma production in response to heat killed B. mallei
Owaki et al., J Immunol 2006
:
Finally,
IL-12Rbeta2 expression was shown to be
up-regulated by
IL-27 in both T-bet- and ICAM-1/LFA-1 dependent mechanisms
Fitzgerald et al., J Immunol 2007
(Encephalomyelitis, Autoimmune, Experimental...) :
IL-27 significantly
inhibited both nonpolarized and
IL-23-driven IL-17 production by myelin-reactive T cells thereby suppressing their encephalitogenicity in adoptive transfer EAE
Robinson et al., J Infect Dis 2008
(Tuberculosis) :
Quantitative measurement of transcripts showed that
IL-12 or M. tuberculosis
induced IL-27 gene expression in human macrophages
Zhang et al., Clin Neurol Neurosurg 2010
(Autoimmune Diseases...) :
IFNbeta inhibited IL-1beta,
IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and
induced IL-27 , IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Zeitvogel et al., Exp Dermatol 2012
:
IL-27 acts as a priming signal for
IL-23 but not IL-12 production on human antigen presenting cells ...
IL-27 acts as a priming signal for IL-23 but not
IL-12 production on human antigen presenting cells