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EGF — RELA

Text-mined interactions from Literome

Biswas et al., Proc Natl Acad Sci U S A 2000 (Breast Neoplasms) : An inhibitor of phosphatidylinositol 3 kinase, Ly294-002, blocked this event, suggesting a role of the former in the activation of NF-kappaB by EGF ... Go6976, a well characterized NF-kappaB inhibitor, blocked EGF induced NF-kappaB activation and up-regulation of cell-cycle regulatory proteins
Habib et al., J Biol Chem 2001 : Our studies also suggest that a high level of EGFR expression, a frequent occurrence in human tumors, is optimal for epidermal growth factor induced NF-kappaB activation
Hirota et al., J Biol Chem 2001 : We have demonstrated that overexpression of the EGF receptor (EGFR) in NIH3T3 cells significantly enhances TNF induced NF-kappa B-dependent luciferase activity even without EGF, that EGF treatment has a synergistic effect on the induction of the reporter activity, and that this enhancement is suppressed by AG1478, EGFR-specific tyrosine kinase inhibitor
Loukinova et al., Int J Cancer 2001 (Carcinoma, Squamous Cell...) : In our study, we investigated the effect of the regulatory cytokines, IL-1alpha, EGF and TGF-beta1 on activation of NF-kappaB and Gro1 in primary and metastatic sublines of the murine SCC Pam 212
Bancroft et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : In our study, we examined the effect of EGF and antagonists of EGFR, PI3K and MEK on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in HNSCC cell lines UM-SCC-9 and 11B in which EGFR is overexpressed and activated ... Recombinant EGF induced EGFR phosphorylation, activation of NF-kappaB and AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC
Li et al., Clin Cancer Res 2002 (Prostatic Neoplasms) : Moreover, genistein abrogated the epidermal growth factor induced activation of NF-kappaB , which was mediated via Akt signaling pathway
Jiang et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : However, either PDGF or EGF markedly enhanced interleukin-1beta induced persistent NF-kappaB activation and iNOS expression but did not affect the early and transient NF-kappaB activation ... These results indicate that interleukin-1beta induced expression of NF-kappaB dependent genes, such as iNOS, is potentiated in the presence of growth factors through a mechanism requiring ERK dependent enhanced NF-kappaB activation, and the results also suggest that NF-kappaB activation is not required for PDGF or EGF to trigger DNA synthesis in VSMCs
Biswas et al., Cancer Res 2003 (Adenocarcinoma...) : Both the protein kinase C (alpha/beta) inhibitor Go6976 and expression of dominant negative nuclear factor (NF)-kappaB inhibitor kinase mutants : ( a ) blocked the growth and caused regression of a mammary tumor insyngeneic mice ; ( b ) inhibited epidermal growth factor (EGF) induced activation, nuclear translocation, and DNA binding activity of NF-kappaB ; and ( c ) caused apoptosis of EGF stimulated cultured mammary tumor cells
Ediger et al., Eur Respir J 2003 (Cell Transformation, Neoplastic...) : In contrast, nuclear factor (NF)-kappaB was activated by LPA but not EGF and NF-kappaB activation was completely blocked only when Rho was inhibited
Banan et al., J Pharmacol Exp Ther 2003 : 2 ) EGF ( 10 ng/ml ) stabilized I-kappaBalpha and prevented both NF-kappaB translocation and activation while protecting monolayers against oxidants
Chen et al., Oncogene 2003 : In reporter gene assays, NIK could potentiate Grb7, ErbB2/ErbB4, and EGF induced NF-kappaB activation ... A NIK kinase inactive mutant could block ErbB2/ErbB4 and EGF induced NF-kappaB activation ... Moreover, EGF/heregulin receptors activated NF-kappaB in wild-type, but not NIK-/- embryonic fibroblasts
Yang et al., Mol Pharmacol 2003 : The D2R mediated NF-kappaB activation was not dependent on epidermal growth factor (EGF) receptor transactivation since 4- ( 3'-chloroanilino ) -6,7-dimethoxyquinazoline ( AG1478 ), an EGF receptor-selective tyrphostin used at 1 microM, blocked EGF induced NF-kappaB activation but not the quinpirole induced response
Banan et al., J Pharmacol Exp Ther 2003 : In an attempt to investigate, at the molecular level, the fundamental events underlying EGF protection against oxidant disruption, we tested the intriguing hypothesis that EGF induced activation of PKC-zeta prevents oxidant induced activation of NF-kappaB and the consequences of NF-kappaB activation, namely, cytoskeletal and barrier disruption
Banan et al., Am J Physiol Cell Physiol 2004 : We hypothesized that EGF induced activation of PKC-beta1 prevents oxidant induced activation of NF-kappaB and the consequences of NF-kappaB activation, F-actin, and barrier dysfunction
Rahman et al., Nutr Cancer 2004 (Breast Neoplasms) : In addition, I3C also abrogated the EGF induced activation of NF-kappaB , which was mediated via the Akt signaling pathway
Klooster et al., Arthritis Res Ther 2005 (MAP Kinase Signaling System) : EGF alone did not activate NF-kappaB or alter NF-kappaB activation by TNF-alpha
Sitcheran et al., EMBO J 2005 : Additionally, the regulation of NF-kappaB by EGF is poorly understood ... Herein, we demonstrate that both TNFalpha mediated repression and EGF mediated activation of EAAT2 expression require NF-kappaB ... We show that EGF activates NF-kappaB independently of signaling to IkappaB
Häussler et al., American journal of physiology. Renal physiology 2005 : Furthermore, both EGF mediated NF-kappaB activation and cyclin D1 expression were inhibited by coexpression of super IkappaB
Zhang et al., Pancreas 2006 (Neoplasm Invasiveness...) : Furthermore, EGF stimulated NF-kappaB binding activity ... Moreover, pretreatment of cells with NF-kappaB inhibitors, pyrrolidine dithiocarbamate or ibuprofen, markedly attenuated EGF induced NF-kappaB activation
Singh et al., Mol Cancer Ther 2006 (MAP Kinase Signaling System) : Silibinin treatment under similar conditions also strongly inhibited EGF induced ERK1/2, JNK1/2, and p38K as well as Akt phosphorylation, and also suppressed EGF induced AP-1 and NF-kappaB activation
Ahn et al., J Biol Chem 2007 : Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor
Sethi et al., Oncogene 2007 (Adenocarcinoma...) : EGF activated NF-kappaB DNA binding, induced NF-kappaB reporter activity and the expression of antiapoptotic and cell-proliferative gene products ... Although DN-IKKbeta inhibited TNF induced NF-kappaB activity, DN-IKKbeta had no effect on EGF induced NF-kappaB activation, suggesting that EGF induced NF-kappaB activation is IKK independent ... Using dominant negative plasmids, we also demonstrated the role of TRADD, TRAF2, NIK and Ras in EGF induced NF-kappaB activation ... Furthermore, EGF receptor kinase inhibitor blocked IkappaBalpha phosphorylation and consequent NF-kappaB activation
Nakamura et al., Rheumatol Int 2007 (Sjogren's Syndrome) : EGF activates PI3K-Akt and NF-kappaB via distinct pathways in salivary epithelial cells in Sjögren 's syndrome ... Chemical inhibition of PI3K-Akt by LY294002/wortmannin did not affect EGF mediated NF-kappaB p65 nuclear translocation ; and NF-kappaB inhibition by Bay 11-7082 did not suppress Akt phosphorylation ... Our data suggest that EGF stimulates both the PI3K-Akt pathway and NF-kappaB via distinct mechanisms, promoting tropic effects in SS salivary epithelial cells
Zhang et al., Zhonghua Zhong Liu Za Zhi 2007 (Neoplasm Invasiveness...) : Furthermore, EGF stimulated the NF-kappaB binding activity, and pretreatment of cells with a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated EGF induced NF-kappaB activation
Huang et al., Oncogene 2008 (Neoplasms) : ABINs inhibit EGF receptor mediated NF-kappaB activation and growth of EGF receptor overexpressing tumour cells ... However, the mechanisms that regulate EGF induced NF-kappaB activation are still largely unknown ... Here we show that EGF can induce NF-kappaB dependent gene expression independently from IkappaBalpha degradation or p100 processing in EGFR overexpressing HEK293T cells ... Moreover, EGF induced NF-kappaB activation could be inhibited by overexpression of ABINs, which were previously identified as intracellular inhibitors of tumour necrosis factor, interleukin-1 and lipopolysaccharide induced NF-kappaB activation
Kuo et al., J Agric Food Chem 2009 (Bone Neoplasms...) : The results showed that 5GG suppressed the EGF induced NF-kappaB nuclear translocation and also abrogated the EGF induced activation of c-jun N-terminal kinase ( JNK ), an upstream modulator of NF-kappaB
Nah et al., Rheumatol Int 2010 (Arthritis, Rheumatoid) : Electrophoretic mobility shift assay ( EMSA ) was performed to investigate EGF mediated DNA binding activity of nuclear factor-kappaB (NF-kappaB) ... The DNA binding activity of NF-kappaB was remarkably increased by EGF treatment and the pretreatment of PD098059 abolished EGF stimulated NF-kappaB activity
Guo et al., Proc Natl Acad Sci U S A 2011 : FER tyrosine kinase ( FER ) overexpression mediates resistance to quinacrine through EGF dependent activation of NF-kappaB
Miller et al., J Virol 1997 : The Epstein-Barr virus ( EBV ) -encoded LMP1 protein induces several cellular changes including induction of epidermal growth factor receptor (EGFR) expression and activation of the NF-kappaB transcription factor
Sun et al., Oncogene 1998 : EGF activates NF-kappaB in A-431 carcinoma cells, which overexpress EGF receptors and in mouse embryo fibroblasts, which have a normal complement of receptors ... Supershift experiments indicate that the NF-kappa-B complexes induced by EGF are composed of p50/p50 homodimers and p65/p50 heterodimers, but not c-rel. EGF stimulation enhances the degradation of IkappaBalpha, but not IkappaBbeta nor an N-terminal deletion mutant of IkappaBalpha ... Treatment of cells with a proteasome inhibitor, such as ALLN or MG132, blocks EGF mediated NF-kappaB activation, indicating that EGF induced NF-kappa-B activation requires proteasome dependent IkappaB degradation ... Also, Bapta A/M ( a cell-permeable chelator of intracellular calcium ) blocks EGF induced NF-kappa-B activation and IkappaBalpha degradation, suggesting a requirement of intracellular free Ca2+ for this growth factor response ... Protein kinase C inhibition, in contrast, did not influence EGF activation of NF-kappaB