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PIM1 — STAT5A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Peltola et al., Blood 2004
:
Ectopic expression of
Pim-1 in cytokine dependent FDCP1 myeloid cells
results in reduced tyrosine phosphorylation and DNA binding of
STAT5 , indicating that Pim-1 interferes already with the initial steps of STAT5 activation
Wernig et al., Blood 2008
(Cell Transformation, Neoplastic...) :
An inducible constitutively active
STAT5 mutant expressed in BaF3 cells was
sufficient to induce Myc and
Pim
Sathyanarayana et al., Blood 2008
:
EPOR survival circuits therefore include the repression of Bim plus FoxO3a, and
EPOR/PY343/STAT5 dependent stimulation of
Pim1 , Pim3, Irs2 plus Serpina-3G, and Trb3 as new antiapoptotic effectors
Vu et al., Biochem Biophys Res Commun 2009
:
The wild-type ETV6/FLT3 fusion protein in transfected cells was a constitutively activated tyrosine kinase that led to up-regulation of
PIM-1 and
activations of
STAT5 , AKT, and MAPK