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CXCR4 — SDF2
Text-mined interactions from Literome
Rempel et al., Clin Cancer Res 2000
(Astrocytoma...) :
In tumors,
SDF1 and CXCR4 expression was colocalized when both were expressed, and SDF1 and
CXCR4 expression
increased with increasing tumor grade ( from 0.5+ to 6+ )
Yuecheng et al., Eur J Cancer Prev 2007
(Neoplasm Invasiveness...) :
In ovarian cancer cells,
SDF-1 stimulation
resulted in increased
CXCR4 expression at both the transcription and protein levels
Taki et al., Oncol Rep 2008
(Carcinoma, Squamous Cell...) :
Furthermore,
SDF-1alpha and TGF-beta1
up-regulated the expression of
CXCR4 and cell migratory activity in these cells
Tesio et al., Blood 2011
:
Interestingly,
stromal cell derived factor 1/CXC
chemokine receptor-4 signaling
induced hepatocyte growth factor production and c-Met activation
Olbrich et al., Gynecol Oncol 2010
(Bone Neoplasms...) :
Furthermore,
SDF-1 induced
CXCR4 signaling was down-regulated
Fan et al., Inflammation 2012
(Disease Models, Animal...) :
The chemokine
CXC receptor 4 (CXCR4) is
activated by
stromal cell derived factor ( SDF-1a )