◀ Back to PPARA

ACOX1 — PPARA

Pathways - manually collected, often from reviews:

• BioCarta mechanism of gene regulation by peroxisome proliferators via ppara: PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1) → PPRE-Regulated proteins (LPL/APOA1/CPT1A/HSD17B4/APOA2/ME1/ACOX1/NR1H3/FABP1/EHHADH) (transcription, inhibits)
  
• KEGG PPAR signaling pathway: Complex of PPARA-RXRA-RXRB-RXRG → ACOX1/ACOX2/ACOX3 (gene expression, expression)
• WikiPathways PPAR signaling pathway: Complex of RXRA-PPARA-RXRG-RXRB → ACAA1/CYP4A11/CYP4A11/ACOX1/CYP4A11/CYP4A11/ACADM/CPT1B/CPT1C/CYP4A11/CYP4A11/ACOX3/ACOX2/CPT2/CYP4A11/CYP4A11/SCP2/CPT1A/EHHADH/ACADL/ACAA1 (mim-transcription-translation)
  

Text-mined interactions from Literome

Jump et al., Lipids 1999 : Using the peroxisome proliferator activated receptor alpha ( PPAR alpha ) -null mouse, we showed that dietary PUFA induction of acyl CoA oxidase (AOX) and CYP4A2 require PPAR alpha
Yeldandi et al., Mutat Res 2000 (Cell Transformation, Neoplastic...) : Thus, the substrates of acyl-CoA oxidase serve as endogenous ligands for this receptor leading to a receptor-enzyme cross-talk, because acyl-CoA oxidase gene is transcriptionally regulated by PPARalpha
Johnson et al., J Steroid Biochem Mol Biol 2001 : Of the PPs and fatty acids tested, there was a strong correlation between the ability of these agents to suppress de novo sterol synthesis in a rat hepatoma cell line, H4IIEC3, and inhibit LXR mediated transcription in COS-7 cells, but a discordance between these endpoints and PPARalpha activation and fatty acid acyl-CoA oxidase induction
Yoon et al., Br J Pharmacol 2003 : 2. In vivo administration of ginseng extract ( GE ) and ginsenosides ( GS ) not only inhibited mRNA levels of acyl-CoA oxidase , a rate limiting enzyme for PPARalpha mediated peroxisomal fatty acid beta-oxidation, induced by the potent PPARalpha ligand Wy14,643 in a dose- and time dependent manner, but also inhibited the induction of PPARalpha target genes expected following treatment with Wy14,643
Latruffe et al., C R Seances Soc Biol Fil 1992 : Mouse PPAR and Xenopus PPAR 's ( alpha, beta and upsilon ) activate the rat peroxisomal acyl CoA oxidase gene by recognition of specific responsive elements containing the 5'flanking `` TGACCT '' repeated sequence in the -560 upstream region
Yeon et al., J Gastroenterol Hepatol 2004 (Disease Models, Animal...) : AOX , regulated by PPAR-alpha , also increased to 149 % and 120 % of the control
Kane et al., Gene 2006 : Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPARalpha ... Thus we have focused on elucidating the molecular mechanism of species dependent peroxisome proliferation by understanding the PPARalpha dependent regulation of the acyl-CoA oxidase (AOX) promoter, the rate limiting step of peroxisomal beta-oxidation ... Taken together, we demonstrate concordant regulation of the AOX promoter by PPARalpha in cynomolgus monkeys and humans and suggest that this model is superior to rodent models with respect to preclinical evaluation of PPARalpha agonists