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SLC22A3 — TLR4
Text-mined interactions from Literome
Jing et al., BMC medicine 2012
(Carcinoma, Hepatocellular) :
The in vitro and in vivo experiments demonstrated that LPS could significantly enhance the invasive potential and
induce EMT in HCC cells with
TLR4 dependent ... Our results indicate that
TLR4 signaling is
required for LPS induced
EMT , tumor cell invasion and metastasis, which provide molecular insights for LPS related pathogenesis and a basis for developing new strategies against metastasis in HCC
Liu et al., Lab Invest 2013
(Adenocarcinoma...) :
Activation of TLR4 on M2-polarized TAMs stimulates an increase in the cytokine interleukin-10 (IL-10) ; consequently, another aim was to investigate the potential
role of
TLR4/IL-10 signaling in the
EMT of pancreatic cancer ... Furthermore, activation of
TLR4 signaling by lipopolysaccharide profoundly
increased the
EMT of pancreatic cancer cells