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IL13 — IL2

Text-mined interactions from Literome

Hoshino et al., J Immunol 1999 : In contrast, IL-12 did not enhance the IL-13 production induced by IL-2 alone ... These results suggest IL-13 expression induced by IL-2 + IL-18 may be regulated by IFN-gamma in vivo, while IL-10 expression may be IFN-gamma independent
Liu et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 1997 (Yang Deficiency) : Hemorheological indexes, brain noradrenaline ( NE ), adrenocorticotropine ( ACTH ), beta endorphin, cortisol, estradiol, testosterone, interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen 's lymphocyte transformation and induction of IL-2 and the activity of natural killer cells ( NKC )
Song et al., Neuroscience 1999 : As well, interleukin-6 and interleukin-2 were both found to reduce the homovanillic acid response associated with the stress, and interleukin-2 promoted a decline of homovanillic acid levels
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA
Verheyen et al., Scand J Immunol 2000 : Regulation of interleukin-2 induced interleukin-5 and interleukin-13 production in human peripheral blood mononuclear cells ... In anti-CD3 treated peripheral blood mononuclear cells, IL-2 induced IL-5 and IL-13 alongside IFN-gamma, IL-10 and IL-12 ... In the presence of IL-2 , inhibition of endogenous IL-12 production further enhanced the IL-5 and IL-13 responses, while IFN-gamma and IL-10 were markedly suppressed
Matsuura et al., Dig Liver Dis 2000 (Crohn Disease) : The effect of interleukin-4 on lamina propria mononuclear cells from Crohn 's disease, ulcerative colitis and control mucosa was assessed on various T-cell functions : interleukin-2 induced cytotoxicity, soluble interleukin-2 receptor and interleukin-2 production, and expression of mRNA for interleukin-2R and interferon-gamma
Kelley et al., Lipids 2001 : CLA supplementation did not alter the in vitro secretion of prostaglandin E2, leukotriene B4, interleukin-1beta (IL-1beta), or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide, and the secretion of IL-2 by PBMC stimulated with phytohemagglutinin
Chakir et al., Cell Immunol 2001 : DX5+ splenocytes showed a rapid ( 6 h ) and sustained ( 6-72 h ) accumulation of IFN-gamma transcripts followed by a delayed ( 12-24 h ) up-regulation of IL-10 or IL-13 expression in response to IL-2 + IL-12 or IL-2 + IL-18, respectively ... Last, we demonstrate that DX5+ cells respond to IL-18 independently of IL-12, as cells from both wild-type and IL-12Rbeta2KO mice produce IFN-gamma and IL-13 in response to IL-2 + IL-18
Dalhoff et al., Lancet Infect Dis 2003 : In general, most fluoroquinolone derivatives superinduce in-vitro interleukin 2 synthesis but inhibit synthesis of interleukin 1 and tumour necrosis factor (TNF)alpha ; furthermore, they enhance significantly the synthesis of colony stimulating factors (CSF)
Macphail et al., J Immunol 2003 : This was accompanied by reduced PHA induced IL-2 release and reduced IL-2, IFN-gamma, and IL-13 mRNA expression
Sugimoto et al., J Exp Med 2004 (Bronchial Hyperreactivity...) : Newly polarized Th1 cells and IFN-gamma expressing Th1 cells, both of which express IL-18 receptor alpha chain strongly, produce IFN-gamma, IL-9, IL-13 , granulocyte/macrophage colony stimulating factor, tumor necrosis factor alpha, regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein 1alpha upon stimulation with Ag, IL-2 , and IL-18 in vitro
Melk et al., Transplantation 2004 (Growth Disorders...) : During rhGH therapy in children with transplants, interleukin (IL)-2 production increased threefold at 4 weeks, and IL-4 and IL-13 increased by 70 % at 12 weeks
Rodriguez-Galán et al., J Immunol 2005 : The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and IL-13 expression is dependent on Stat4 and NF-kappaB but independent of Stat6, T-bet, or NFAT
Hashimoto et al., Int Arch Allergy Immunol 2006 : IL-2 induced IL-13 production by allergen-specific human helper T cell clones ... IL-13 production was clearly induced by IL-2 ... The IL-2 signal by itself causes IL-13 synthesis independent of T cell receptor stimulation
Fernández et al., Appl Environ Microbiol 2007 : Furthermore, expression of a mature mouse IL-2 gene resulted in interleukin secretion without the requirement for a leader sequence
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Tomizawa et al., Clin Exp Immunol 1991 : Of the cytokines studied, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) were involved in the regulation of IL-2R on B cells
Loza et al., Respir Res 2010 (Asthma) : An ex vivo system was used to characterize the regulation of IFN-gamma producing ( type 1 ) and IL-13 producing ( type 2 ) T cell accumulation in response to CD3+CD28 and IL-2 stimulation by flow cytometry
Scholz et al., Cell Signal 1989 (Leukemia) : Synergistic induction of interleukin 2 receptor ( TAC ) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents
Schultzberg et al., Neuroscience 1989 : These antisera also inhibited stimulation of interleukin-2 receptor expression by purified human interleukin-1
Falk et al., Lymphokine Res 1989 : The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression
Lee et al., J Rheumatol 1985 (Arthritis...) : The low IL-2 levels was not a result of degradation or consumption of endogenously produced interleukin
Anastassakos et al., Clin Exp Immunol 1987 (Chronic Disease...) : To test the hypothesis that reduced lymphocyte transformation in response to PHA in chronic hepatitis B virus infection might be due to deficient lymphokine production, lymphocyte transformation was measured in the presence or absence of exogenous interleukin 1, interleukin 2 or both, or, as a source of mixed lymphokines, supernatants from mixed lymphocyte reactions
Uchiyama et al., Microbiol Immunol 1986 : T cells obtained by the nylon wool column method alone produced IL 2 on TSST-1 stimulation in the presence of either macrophages or a macrophage lysate containing interleukin 1
Mukaida et al., J Immunol 1987 (Leukemia) : Signal requirement for interleukin-1 dependent interleukin 2 production by a human leukemia derived HSB.2 subclone
Soulillou et al., Eur J Cancer Clin Oncol 1985 (Hodgkin Disease) : Peripheral blood lymphocytes ( PBL ) of patients with Hodgkin 's disease were studied for their capacity to produce interleukin 2 upon in vitro phytohemaglutinin stimulation in the presence or absence of either interleukin 1 or indomethacin ( 2 micrograms/ml ) ; eight patients were studied at the discovery of their disease before receiving any therapy ( onset HD ; OHD )
Solbach et al., Blood 1984 (Sezary Syndrome) : In this article we have studied the effects of the immunosuppressive drug cyclosporine A ( CsA ) on growth, interleukin-2 (IL-2) production, and the induction of IL-2 responsiveness of peripheral blood monocytes ( PBMs ) from five patients with Sézary 's syndrome in vitro, using the lectin phytohemagglutinin ( PHA ) and the phorbol ester phorbol myristate acetate ( PMA ) as stimuli
Knop et al., Hautarzt 1984 (Dermatitis, Atopic...) : The production of interleukin 2 is induced by interleukin 1, which can be also produced by keratinocytes ( epidermal T-cell activating factor, ETAF )
Bunjes et al., Eur J Immunol 1981 : The selective effects included a blockade of interleukin 2 release from activated T helper cells on the one hand and inhibition of interleukin 1 release from splenic adherent cells on the other
Hersey et al., J Immunol 1983 (Cell Transformation, Neoplastic...) : These supernatants did not inhibit interleukin 1 production, and also did not inhibit the mitogenic activity of performed IL 2 on IL 2-dependent target cells
Okada et al., Proc Natl Acad Sci U S A 1981 : In a clone ( 38-B ) that did not show any IL-2 activity in culture supernatants, the addition of macrophages induced IL-2 production in the presence of phytohemagglutinin, suggesting that interleukin-1 induced IL-2 production in T hybrid cells
Musso et al., J Exp Med 1994 : We have found that Lsk mRNA and protein were not expressed in resting monocytes but were induced by treatment with interleukin 4 (IL-4) or IL-13 but not by interferon gamma (IFN-gamma) or IL-2
Kees et al., J Immunol Methods 1994 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : A new human cell line for the molecular dissection of the requirement for interleukin-1 in the production of interleukin-2 by immature T cells
Armant et al., Eur J Immunol 1996 : Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement : involvement in interleukin-2 induced interleukin-12 and interferon-gamma production
Yu et al., J Immunol 1998 : In T cells, IL-13 inhibits anti-CD3 mAb/IL-2- or PHA mediated IFN-gamma production and enhances cytolytic potential
Hoshino et al., J Immunol 1999 : Six of 12 human NK clones tested produced IL-13 protein in response to IL-2 or phorbol myristate acetate and ionomycin ... Intracellular analysis revealed that approximately 2 % of human peripheral NK cells produced IL-13 protein in response to IL-2