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FOXO4 — IGF1

Text-mined interactions from Literome

Hansen et al., PLoS Genet 2008 : Long lived daf-2 insulin/IGF-1 receptor mutants require both autophagy and the transcription factor DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16
Essaghir et al., J Biol Chem 2009 : PDGF, fibroblast growth factors ( FGF ), and IGF-I repressed the expression of FOXO genes in human fibroblasts
Cleveland et al., Am J Physiol Regul Integr Comp Physiol 2010 : IGF-I and insulin stimulated phosphorylation of FOXO1 and FOXO4 ( P < 0.05 ), which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin, and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 )
Kenyon et al., Ann N Y Acad Sci 2010 : However, the mechanisms by which inhibition of insulin/IGF-1 signaling and germline loss activate DAF-16/FOXO are distinct
Löw et al., Gen Comp Endocrinol 2011 (Nerve Degeneration) : Longevity increases when FoxO becomes activated in response to reduced insulin/IGF-1 signalling