◀ Back to MAPK3
GRB2 — MAPK3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK3
→
Complex of ACP1-GRB2
(increases, ACP1/GRB2 Activity)
Evidence: The redox-dependent enhancement of Grb2 recruitment to LMW-PTP ultimately leads to an improvement of ERK activation, likely triggering a prosurvival signal against the oxidant environment.
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OpenBEL Selventa BEL large corpus:
MAPK3
→
Complex of GRB2-KIT
(increases, GRB2/KIT Activity)
Rönnstrand et al., Cell Mol Life Sci 2004*
Evidence: The adapter protein Grb2 can directly associate with phosphorylated Y703 and Y936 in c-Kit
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OpenBEL Selventa BEL large corpus:
MAPK3
→
Complex of GRB2-SOS1
(increases, GRB2/SOS1 Activity)
Blaukat et al., J Biol Chem 1999*
Evidence: the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway.
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KEGG Osteoclast differentiation:
GRB2
→
MAPK1/MAPK3
(protein-protein, activation)
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NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
Erk1-2 (MAPK3/MAPK1)
→
HGF(dimer)/MET(dimer)/GRB2/GAB1/SHP2 complex (MET-GRB2-GAB1-PTPN11-HGF)
(modification, collaborate)
Schaeper et al., J Cell Biol 2000, Maroun et al., Mol Cell Biol 2000
Evidence: mutant phenotype
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NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
SHP2 (PTPN11)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database ErbB4 signaling events:
Erk1-2 (MAPK3/MAPK1)
→
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC complex (ERBB4-NRG1-GRB2-SHC1)
(modification, collaborate)
Vaskovsky et al., J Neurochem 2000, Ma et al., J Neurosci 2003
Evidence: mutant phenotype
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NCI Pathway Database VEGFR3 signaling in lymphatic endothelium:
Erk1-2 (MAPK3/MAPK1)
→
SHC/GRB2/SOS1 complex (SOS1-GRB2-SHC1)
(modification, collaborate)
Salameh et al., Blood 2005
Evidence: assay
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Reactome Reaction:
GRB2
→
MAPK3
(reaction)
Waters et al., Mol Cell Biol 1995, Corbalan-Garcia et al., Mol Cell Biol 1996*
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WikiPathways Insulin Signaling:
RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10
→
MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14
(activation)
Text-mined interactions from Literome
Uchida et al., Mol Cell Biol 2000
:
Insulin
promoted the association of
Grb-2 with IRS-1 and IRS-4, whereas IRS-2 weakly bound Grb-2 ; consequently, IRS-1 and IRS-4 enhanced insulin stimulated
mitogen activated protein kinase activity
Zhou et al., J Immunol 2000
:
In contrast, the phosphorylation of LAT and enhanced association with
Grb2 led to activation of extracellular signal regulated kinase ( ERK )
mitogen activated protein kinase
Wang et al., Oncogene 2000
(Bone Neoplasms...) :
The specific effect of LAR on FGF induced
MAPK activation appeared to be
mediated by specific inhibition of the phosphorylation of two signal transducers that act downstream of the FGF receptor, FRS2 and a 180 kDa protein, and by prevention of their interaction with the adaptor protein
GRB2
Weng et al., Hum Mol Genet 2001
(Breast Neoplasms) :
PTEN
inhibits insulin stimulated
MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and
IRS-1/Grb-2/Sos complex formation in a breast cancer model
Leshem et al., Exp Cell Res 2002
(MAP Kinase Signaling System) :
Whereas enhanced
Grb2 binding
increased the phosphorylation of the
mitogen activated protein kinase/extracellular signal regulated protein kinases ( MAPK/ERK ) and abrogated that of p38 MAPK, PI3K had the opposite effect
Guilloton et al., Cell Signal 2007
(Leukemia, Myeloid, Acute) :
The effects of TNFalpha and FasL on
GrB expression were specifically
mediated by
p38MAPK ( Mitogen-activated-protein-kinase ) activation
Smith et al., EMBO J 2010
:
The ShcA adaptor contains two phosphotyrosine recognition modules responsible for binding activated receptors, resulting in the subsequent recruitment of
Grb2 and
activation of
Ras/MAPK
Tanaka et al., Mol Cell Biol 1995
:
Activation of
Erk-1 by oncogenic Abl was effectively
inhibited by
Grb2 with mutations in either its SH2 or SH3 domain or by Crk-1 with an SH3 domain mutation
Maru et al., J Cell Physiol 1998
:
Matrigel induced long lasting tyrosine phosphorylation of Shc, with recruitment of
Grb-2 and microtubule associated protein kinase (
MAPK )
activation in both parental NP31 and NP31 transformed by ts-v-Ras, which was blocked by anti-beta1 integrin antibody
Walker et al., Mol Cell Biol 1998
:
Analysis of the early signalling events by the WT, V741G, and Y740F mutant EGF receptors indicated that EGF stimulates comparable levels of Shc phosphorylation,
Shc-GRB-2 association, and
activation of Ras, B-Raf, and
Erk-1