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CXCL12 — PAK1

Text-mined interactions from Literome

Wang et al., Biochemistry 2002 : Moreover, CXCL1 activation of PAK1 is independent of ERK1/2 activation, a conclusion based on the observations that the inhibition of MEK-ERK activation by expression of dominant negative ERK or by the MEK inhibitor, PD98059, has no effect on CXCL1 induced PAK1 activation or CXCL1 induced chemotaxis
Wang et al., Biochemistry 2003 : Moreover, CXCL10 can inhibit CXCL1 induced PAK1 and ERK activation as well as the CXCL1 induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate
Volinsky et al., Biochem J 2006 : Pak(i) potently inhibited SDF-1alpha induced Pak activation by a bivalent mechanism, as indicated by its complete inactivation upon point mutation of two binding sites, but partial inactivation upon mutation of either site alone ... SDF-1alpha induced Pak activation was partly dependent on PIX ( Pak-interactive exchange factor ) ; correspondingly, an allele of beta-PIX that can not bind Pak inhibited SDF-1alpha induced chemotaxis through small, but not large pores