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CD44 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: TP53 — CD44 (interaction, mapped from intact)
• STRING interaction: CD44 — TP53 (interaction, mapped from intact)

Text-mined interactions from Literome

Godar et al., Cell 2008 : Here, we show that under conditions of basal physiologic and cell-culture stress, p53 inhibits expression of the CD44 cell-surface molecule via binding to a noncanonical p53 binding sequence in the CD44 promoter
Sohr et al., Cell cycle (Georgetown, Tex.) 2008 : Additionally, p53 dependent downregulation is consistent with an oncogenic function of RHAMM and the recently reported tumor-suppressive function of CD44 transcriptional repression by p53
Mandal et al., J Biol Chem 2011 (Bone Neoplasms...) : shRNA derived inhibition of mutant p53R280K augmented the expression of CD44 , leading to increased migration and invasion
Ren et al., Int J Oncol 2013 (Prostatic Neoplasms) : Moreover, WT-p53 also suppressed colony formation, tumor sphere formation and expression of CSC markers and stemness factors including CD44 , Oct4, c-Myc and Klf4 in PC-3 cells
Zeilstra et al., PloS one 2013 : In the present study, we therefore explored the relation between p53 mutational status and CD44 expression in a cohort of 90 localized primary CRCs and studied the effect of radiation induced p53 activation on CD44 expression ... Our data demonstrate that CD44 expression in normal and malignant intestinal epithelial cells is not regulated by p53 , implying that regulation of this potentially important therapeutic target is tissue and cancer-type specific