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TCHP — TP53
Text-mined interactions from Literome
Nickells et al., Surv Ophthalmol 1999
(Glaucoma) :
One of the primary regulatory steps is the
activation of the
tumor-suppressor protein ,
p53
Weber et al., Mol Cell Biol 2000
:
The ARF
tumor suppressor protein stabilizes
p53 by antagonizing its negative regulator, Mdm2 ( Hdm2 in humans )
Li et al., Proc Natl Acad Sci U S A 2001
:
The p53
tumor suppressor protein and the MDM2 oncoprotein form a feedback-control loop that up-regulates cellular MDM2 production,
blocks p53 activity, and promotes p53 decay
Zilfou et al., Mol Cell Biol 2001
:
Interestingly, unlike retinoblastoma
tumor suppressor protein , MDMX, and p14(ARF), Sin3
stabilizes p53 in an MDM2 independent manner
Yakovlev et al., J Biol Chem 2004
:
Thus, DNA damage induced apoptosis requires new protein synthesis, accumulation of p53
tumor suppressor protein , and
p53 dependent
induction of BOK and NOXA genes, while a role for BAX in this pathway is not essential
den Besten et al., Cell cycle (Georgetown, Tex.) 2005
(Leukemia, Myeloid, Acute) :
Myeloid leukemia associated nucleophosmin mutants perturb
p53 dependent and independent activities of the Arf
tumor suppressor protein
Vaskivuo et al., Toxicol Appl Pharmacol 2006
(Ovarian Neoplasms) :
p14(ARF)
tumor suppressor protein regulates
p53 by interfering with mdm2-p53 interaction
Zakharova et al., Mol Biol (Mosk) 2011
:
A novel mode of the
tumor suppressor protein p53 regulation , mediated by recruitment of the linker histone H1 to the promoters of p53 target genes leading to specific repression of p53 dependent transcription, has recently been uncovered
Wada et al., Bioorg Med Chem Lett 2012
:
Inhibition of
tumor suppressor protein p53 dependent transcription by a tetramerization domain peptide via hetero-oligomerization
Dai et al., J Biol Chem 2012
:
The ARF
tumor suppressor protein activates
p53 in response to oncogenic stress, whereas ribosomal protein L11 induces p53 following ribosomal stress
Dunna et al., Asian Pac J Cancer Prev 2012
(Leukemia, Myeloid, Acute...) :
TP53 is the mostly commonly mutated gene in many cancers and the P53
tumor suppressor protein is
involved in multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control and apoptosis