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TNFSF10 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kim et al., Carcinogenesis 2002
:
In contrast,
TRAIL did not further
increase the cadmium induced accumulation of
p53 despite its potentiation effects on the cadmium induced cell death ... Expression of
p53 ( Val135 ) mutant did not
reduce TRAIL- and cadmium mediated cell death
Wagner et al., Cancer Biol Ther 2003
(Lymphoma, Follicular) :
In chemosensitive FL cells, we found that DNA damaging drugs promote apoptosis through
p53 dependent upregulation of the
TRAIL-DR5 receptor, resulting in activation of caspase-8 and downstream executioner caspases, thereby evading bcl-2 mediated suppression of apoptosis
Heikaus et al., Apoptosis 2007
(Carcinoma, Renal Cell...) :
In the sensitive cell line an
upregulation of multiple E2F1- and
p53-inducible proapaptotic and cell-cycle regulating target genes by Topotecan as well as
TRAIL was observed
Kuribayashi et al., Cancer Biol Ther 2008
(Breast Neoplasms...) :
p53 dependent
TRAIL induction in natural killer cells after chemotherapy exposure provides a link between the tumor suppressor p53 and the host immune response during cancer therapy as well as a paracrine mediated cell-extrinsic death response
Farrell et al., J Gastroenterol Hepatol 2009
(Choline Deficiency...) :
The
p53 induced by nutritional stress is biologically active in mediating mitochondrial cell death pathways, but may also be
responsible for
TRAIL receptor expression, thereby linking intrinsic and exogenous apoptosis pathways in NASH
Yu et al., Cell death & disease 2013
(Colonic Neoplasms) :
Noteworthy, this effect was
protein 53 (p53) independent and was
mediated by
TRAIL-receptor 2 (TRAIL-R2) upregulation, demonstrating the applicability of this approach in p53-defective tumors