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HMGA2 — SLC22A3

Text-mined interactions from Literome

Thuault et al., J Cell Biol 2006 : Endogenous HMGA2 mediates EMT by TGF-beta, whereas ectopic HMGA2 causes irreversible EMT characterized by severe E-cadherin suppression
Thuault et al., J Biol Chem 2008 (Neoplasm Metastasis...) : In the present study we investigated the molecular mechanisms by which HMGA2 induces EMT
Zha et al., Mol Cell Biochem 2012 (Neoplasm Invasiveness...) : To our knowledge, this is the first report on the genome-wide analysis of HMGA2 downstream direct targets, and these findings will be valuable in understanding the roles of HMGA2 in EMT
Morishita et al., Cancer Res 2013 : Ectopic expression of HMGA2 in epithelial cells induces epithelial-mesenchymal transition (EMT) , which has been implicated in the acquisition of metastatic characters in tumor cells ... Together our results argued that HMGA2 plays a critical role in EMT by activating the TGFß signaling pathway, thereby inducing invasion and metastasis of human epithelial cancers