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JUN — MYC

Pathways - manually collected, often from reviews:

• BioCarta mechanism of gene regulation by peroxisome proliferators via ppara: PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1) → Non-PPRE-Regulated proteins (NOS2A/TNF/MYC/FAT/COX2/NFKBIA) (transcription, inhibits)
  
• FastForward regulation: JUN → MYC (transcriptional regulation, unknown) Hiebert et al., Proc Natl Acad Sci U S A 1989
  Evidence: DNABINDING, PROMACTIVITY, REG
• FastForward regulation: JUN → MYC (transcriptional regulation, unknown) Mudryj et al., EMBO J 1990*
  Evidence: DNABINDING, PROMACTIVITY, REG
• FastForward regulation: FOS, JUN → MYC (transcriptional regulation, unknown) Hiebert et al., Proc Natl Acad Sci U S A 1989
  Evidence: DNABINDING, PROMACTIVITY, REG
• FastForward regulation: FOS, JUN → MYC (transcriptional regulation, unknown) Mudryj et al., EMBO J 1990*
  Evidence: DNABINDING, PROMACTIVITY, REG
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3) → MYC (MYC) (transcription, activates) Gan et al., J Cell Biol 2008
  Evidence: reporter gene, physical interaction
• WikiPathways Wnt Signaling Pathway and Pluripotency: EP300 → Complex of 11 proteins (activation)
• WikiPathways Wnt Signaling Pathway and Pluripotency: ZBTB33 → Complex of 11 proteins (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — JUN (physical association, affinity chromatography technology) Levy et al., IUBMB Life 2010*

Text-mined interactions from Literome

López-Rodríguez et al., Eur J Immunol 2000 : Analysis of deletion and mutant promoter constructs revealed that, in the absence of additional upstream cisacting elements, an AP-1 binding site at -60 (AP1-60) is required for c-Myc repressor activity
Wang et al., Biochim Biophys Acta 2012 (MAP Kinase Signaling System) : Over-expression of c-Myc in HEK293 cells increases the levels of MAP4K1, MAP4K1 promoter activity, and phospho-c-Jun
Enan et al., Biochem Pharmacol 1995 : Under in situ incubation conditions with explant tissues in culture, TCDD rapidly enhanced the DNA binding activity of the transcriptional factor AP-1 , whereas the same treatment reduced c-Myc DNA binding activity ... On the other hand, in the presence of forskolin, the stimulatory effect of TCDD on AP-1 binding activity and the inhibitory effect on c-Myc were still apparent