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EIF2AK2 — NOS2

Text-mined interactions from Literome

Blair et al., Diabetes 2001 : Furthermore, the genetic absence of PKR did not affect dsRNA + IFN-gamma induced iNOS expression, nitric oxide production, or the inhibitory actions of these agents on glucose stimulated insulin secretion ... These results suggest that 1 ) NF-KB activation is required for dsRNA + IFN-gamma induced iNOS expression, 2 ) PKR is not required for either dsRNA induced NF-kappaB activation or dsRNA + IFN-y induced iNOS expression by islets, and 3 ) PKR is not required for dsRNA + IFN-gamma induced inhibition of glucose stimulated insulin secretion by islets
Maggi et al., J Biol Chem 2002 : PKR does not participate in iPLA ( 2 ) activation or iNOS expression, because dsRNA stimulates iPLA ( 2 ) activity and dsRNA + IFN-gamma induces iNOS expression and nitric oxide production to similar levels by macrophages isolated from PKR ( +/+ ) and PKR ( -/- ) mice
He et al., Eur J Immunol 2013 : The protein kinase PKR is critical for LPS induced iNOS production but dispensable for inflammasome activation in macrophages