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FGF2 — TIMP2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TIMP2 → FGF2 (increases)
  Evidence: Stimulation of endothelial cells by FGF2 causes also the shedding of cell surface membrane vesicles containing MMP-2 and MMP-9 together with the two MMP inhibitors TIMP-1 and TIMP-2. These vesicles stimulate capillary-like structure formation when added to endothelial cells seeded on a solubilized basement membrane preparation (Matrigel) [26].
• OpenBEL Selventa BEL large corpus: TIMP2 → FGF2 (increases)
  Evidence: FGF2 [50] and FGF8b [17] can enhance endothelial cell reorganization onMatrigel.The process requires the activation of the proteolytic machinery, including type IV collagenase(s) and TIMPs production [51] as well as uPA and PAI-1 upregulation [52], a6b1 integrin receptor engagement [53], PECAM-1 [54], and activation of the small GTPase Rac [55].

Text-mined interactions from Literome

Lau et al., Cardiovasc Res 1999 : Furthermore, in both cell types, the secretion of TIMP-2 was enhanced by tPA and PDGF, but not by uPA or bFGF
Toschi et al., Mol Biol Cell 2001 (Acquired Immunodeficiency Syndrome...) : These effects are due to the activation of the membrane-type-1-matrix-metalloproteinase and to the induction of the membrane bound tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) by Tat and bFGF combined, but also to Tat mediated inhibition of both basal or bFGF induced TIMP-1 and -2 secretion
Wen et al., Life Sci 2002 : Northern blot and nuclear run-off assay showed that bFGF not only stimulated the expression of migration related matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) but also enhanced the transcription of proliferation related osteopontin (OPN) and c-jun genes in the quiescent VSMC
Asanuma et al., Kidney Int 2002 : In addition, bFGF enhanced the secretion of TIMP-2 ( 2.75-fold at 20 ng/mL ) and TGF-beta1 enhanced the secretion of cystatin C ( 2.32-fold at 20 ng/mL )
Yasui et al., Digestion 2004 : FGF-2 stimulated MMP-1, MMP-3 and TIMP-1 secretion, but did not affect MMP-2 or TIMP-2 secretion
Nakoman et al., Biochimie 2005 (Carcinoma...) : The effect of bFGF on MMP-2, TIMP-2 , total collagen, and type I collagen levels of normal and carcinoma lung fibroblast cultures was investigated at 0, 10, and 100 ng/ml. Statistical analysis was carried out using the Mann-Whitney-U test and possible correlations were searched using the Spearman correlation analysis method ... It may be concluded that bFGF does not affect MMP-2, TIMP-2 , total collagen, and type-1 collagen levels in fibroblast cultures grown from human carcinoma and normal lung tissues