Gene interactions and pathways from curated databases and text-mining

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MAPK8 — MYC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Whitwam et al., Oncogene 2007 (Cell Transformation, Neoplastic...) : Although both NRAS and KRAS activate mitogen activated protein kinase signaling, only NRAS enhances MYC activity in these cells
Duan et al., Dig Dis Sci 2010 (Bile Duct Neoplasms...) : Our results revealed that the specific MAPK-ERK cascade inhibitor, PD98059, significantly attenuated phosphorylation of c-Myc on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells
Gramling et al., Cell Death Differ 2012 (Cell Transformation, Neoplastic...) : We report the novel findings that Myc alone induced Ras/Mapk pathway signaling, and increased signaling following growth factor stimulation