Gene interactions and pathways from curated databases and text-mining

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MAPK8 — RBBP7

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK8 → RBBP7 (increases, RBBP7 Activity)
    Evidence: Furthermore, we have found that the c-Jun NH2-terminal kinase (JNK) pathway and GADD45, a growth arrest- and DNA damage-inducible gene, are constitutively activated in RbAp46-expressing cells.

Text-mined interactions from Literome

Wu et al., J Clin Invest 2002 (Myotonia Congenita) : These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Bode et al., Immunology 2007 : In contrast, HDAC inhibitors had no effects on upstream nuclear factor-kappaB and mitogen activated protein kinase activation