Fiorentino et al., J Neurosci 2009
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GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses
Kuczewski et al., J Neurochem 2011
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Mechanism of GABAB receptor induced BDNF secretion and promotion of GABAA receptor membrane expression ... In a previous study, we reported that GABA(B) receptor activation triggers secretion of brain derived neurotrophic factor (BDNF) and promotes the functional maturation of GABAergic synapses in the developing rat hippocampus ... In the present study, we show that GABA(B) receptor induced secretion of BDNF relies on the activation of phospholipase C, followed by the formation of diacylglycerol, activation of protein kinase C, and the opening of L-type voltage dependent Ca ( 2+ ) channels