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AHR — CYP3A4

Text-mined interactions from Literome

Gerbal-Chaloin et al., Cell Signal 2006 (Carcinoma, Hepatocellular...) : Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide
Grover et al., Assay Drug Dev Technol 2007 : Here are presented several in vitro methods to detect AHR- and PXR mediated induction of CYP1A2 and CYP3A4 in fresh and cryopreserved primary human hepatocytes, stable transfectants, and transiently transfected immortalized cells
Kumagai et al., Drug Metab Pharmacokinet 2012 : Here we demonstrate that the AhR activators induce CYP3A4 through human pregnane X receptor (PXR) ... AhR activators, polycyclic aromatic hydrocarbons ( PAHs ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD ) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells
Cui et al., Mini Rev Med Chem 2013 : Several mechanisms of these effects have been established, including the potent inhibition on CYP1 and aromatase, allosteric activation of CYP3A4 and/or activation of AhR