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EPHB2 — RUNX2

Text-mined interactions from Literome

Xiao et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Furthermore, a specific ERK1/2 phosphorylation inhibitor, U0126, completely blocked both FGF-2 stimulated Runx2 phosphorylation and osteocalcin promoter activity, indicating that this regulation requires the MAPK pathway
Chen et al., FEBS Lett 2003 : Moreover, inhibition of ERK activity by PD98059 suppressed US augmentation of Cbfa1/Runx2 and osteocalcin mRNA expression
Zayzafoon et al., J Biol Chem 2004 (Bone Neoplasms...) : Finally, we show that Notch and ERK activation are essential for Runx2 DNA binding activity and osteocalcin gene expression in C4-2B cells in response to osteogenic induction
Wang et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : Inhibitors of MEK/ERK signaling blocked up-regulation of the MMP-13 promoter by RUNX2 and FGF2, and also blocked the activation of RUNX2 by FGF2
Celil et al., J Cell Biochem 2005 : Inhibition of MAPK component ERK1/2 did not affect Runx2 gene expression, but inhibited Osx expression and matrix mineralization
Phimphilai et al., J Bone Miner Res 2006 : However, RUNX2 did not increase the ability of this BMP to activate SMAD, ERK , p38, and JNK pathways
Fan et al., J Cell Physiol 2007 (MAP Kinase Signaling System...) : Specifically, a p38 specific inhibitor, SB203580, significantly inhibited stretching induced osterix expression as well as ALP activity, whereas a specific inhibitor of ERK1/2 , U0126, prevented stretching induced Runx2 expression
Zhang et al., Neurosci Lett 2007 (Chronic Disease...) : Taken together, the excitation of CCD neurons might be attributed to the CCD induced activation of ERK , which suppressed the A-type fast inactivating potassium conductance in CCD neurons
Park et al., J Biol Chem 2010 : We previously demonstrated that ERK activation does not affect Runx2 gene expression but that it stimulates Runx2 transcriptional activity ... However, the molecular mechanism underlying Runx2 activation by FGF/FGFR or ERK was still unclear ... As Runx2 protein phosphorylation mediated by ERK directly correlates with Runx2 protein stabilization, acetylation, and ubiquitination, we undertook to identify the ERK dependent phosphorylation sites in Runx2
Jeong et al., Food Chem Toxicol 2010 : Saponins from the roots of Platycodon grandiflorum stimulate osteoblast differentiation via p38 MAPK- and ERK dependent RUNX2 activation ... CKS induced enhancement of RUNX2 and ALP was inhibited by treatment with a p38 inhibitor ( SB203580 ) and an ERK inhibitor ( U0126 )
Jun et al., J Biol Chem 2010 : Erk activation by overexpression of constitutively active MEK1 increased Runx2 transcriptional activity, whereas U0126, an inhibitor of MEK1/2, suppressed basal Runx2 transcriptional activity and BMP induced Runx2 acetylation and stabilization ... On the other hand, knockdown of Smad1 and Smad5 by siRNA suppressed both basal and Erk induced Runx2 protein levels ... Erk activation enhanced the association of Runx2 with p300 and Smad1 ... Taken together these results indicate that Erk signaling increases Runx2 stability and transcriptional activity, partly via increasing p300 protein levels and histone acetyltransferase activity and subsequently increasing Runx2 acetylation by p300
Case et al., Calcif Tissue Int 2011 : Inhibition of flow activated ERK1/2 prevented the increase in osterix mRNA but not Runx2 ; Runx2 phosphorylation was increased by flow, an effect which likely contributes to osterix induction
Ge et al., J Bone Miner Res 2012 (MAP Kinase Signaling System) : RUNX2 , a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and p38 MAP kinase mediated phosphorylation ... Significantly, in the presence of AA, BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally dependent on ERK/MAPK activity
Li et al., J Bone Miner Res 2012 : These findings establish ERK/MAPK mediated phosphorylation of RUNX2 as a critical step in the response of preosteoblasts to dynamic loading and define a novel mechanism to explain how mechanical signals induce gene expression in bone
Lee et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : ERK activation by TNF-a treatment or constitutively active MEK1 overexpression increased Smurf1 expression in a Runx2 dependent manner
Yue et al., Biochim Biophys Acta 2013 : Similar results were obtained in experiments performed in the native tissue in which inhibition of ERK and p38 MAPK increased BK channel activity in the cortical collecting duct (CCD) treated with dynasore