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MAPK1 — MUC5AC
Text-mined interactions from Literome
Takeyama et al., J Immunol 2000
(MAP Kinase Signaling System) :
Neutrophil supernatant induced EGFR tyrosine phosphorylation,
activation of
p44/42mapk , and
MUC5AC synthesis were inhibited by antioxidants ( N-acetyl-cysteine, DMSO, dimethyl thiourea, or superoxide dismutase ) ; neutralizing Abs to EGFR ligands ( EGF and TGF-alpha ) were without effect, and no TGF-alpha protein was found in the neutrophil supernatant ... In contrast, the EGFR ligand, TGF-alpha, increased EGFR tyrosine phosphorylation,
activation of
p44/42mapk , and subsequent
MUC5AC synthesis, but these effects were not inhibited by antioxidants
Casalino-Matsuda et al., Am J Respir Cell Mol Biol 2009
:
We have previously shown that ROS induced
MUC5AC expression in NHBE cells is
dependent on hyaluronan depolymerization and epidermal growth factor receptor
(EGFR)/mitogen activated protein kinase ( MAPK ) activation
Kim et al., J Cell Biochem 2009
:
We examined the
role of
mitogen activated protein kinase ( MAPK ) signaling on
MUC5AC gene expression in airway epithelium
Yang et al., Ann Hepatol 2013
(Cholelithiasis) :
Expression of phosphorylated p38MAPK was upregulated by exogenous PGE2, and
p38MAPK inhibitor
reduced MUC2 and
MUC5AC expression in HIBECs