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CD8B — IL7
Text-mined interactions from Literome
Poszepczynska et al., Blood 2000
(Lymphoma, T-Cell, Cutaneous) :
Functional characterization of an
IL-7 dependent CD4 ( + )
CD8alphaalpha ( + ) Th3-type malignant cell line derived from a patient with a cutaneous T-cell lymphoma
Vudattu et al., Int J Cancer 2007
(Breast Neoplasms) :
Stimulation with recombinant human
IL-7 for 15 min
increased p-STAT5 expression up to 36-97 % in CD4+T-cells and to 26-90 % in
CD8+T-cells obtained from healthy control donors ( n = 19 )
Vranjkovic et al., Int Immunol 2007
(HIV Infections) :
Furthermore,
IL-7 did not
increase the amount of cytoplasmic CD127 in
CD8 ( + ) T cells
Chaput et al., Gut 2009
(Adenocarcinoma...) :
Finally,
interleukin 6 and TGF beta 1 synergistically
induced the generation of
CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Tripathi et al., J Immunol 2010
(Lymphocytic Choriomeningitis) :
In this study, we assessed the
role of
IL-7 , IL-15, and their common signal transducer, STAT5, in maintaining effector CD4 ( + ) and
CD8 ( + ) T cell responses
Ma et al., Scand J Immunol 2011
(Colonic Neoplasms) :
This study aims to investigate the
role of tumour derived Foxhead box P3 (Foxp3) ( +
) interleukin (IL)-17 ( + ) T cells on suppressing tumour-specific
CD8 ( + ) T cells
Lee et al., Proc Natl Acad Sci U S A 2012
(Diabetes Mellitus, Type 1...) :
IL-7 increases , whereas IL-7Ra antibody therapy reduces, the IFN-? producing CD4 ( + ) ( T ( H ) 1 ) and IFN-? producing
CD8 ( + ) T cells
Plumb et al., PloS one 2012
(Orthomyxoviridae Infections) :
We also showed that
IL-7 signaling was
necessary for the generation of a robust influenza A-specific CD4 and
CD8 T cell response and that this requirement is intrinsic to CD8 T cells
Kimura et al., Nat Immunol 2013
:
We now report that naive
CD8 ( + ) T cells
required IL-7 signaling to be intermittent, not continuous, because prolonged IL-7 signaling induced naive CD8 ( + ) T cells to proliferate, produce interferon-? ( IFN-? ) and undergo IFN-? triggered cell death
Höllsberg et al., Proc Natl Acad Sci U S A 1995
:
CD8 T-cell stimulation with the wild-type peptide antigen
led to activation of p56lck kinase activity,
interleukin 2 secretion, cytotoxicity, and clonal expansion