◀ Back to RAC1

CCL2 — RAC1

Text-mined interactions from Literome

Lopes et al., Circ Res 2002 : Rac dependent monocyte chemoattractant protein-1 production is induced by nutrient deprivation
Chen et al., Am J Physiol Heart Circ Physiol 2004 : Expression of dominant negative N17Rac1 by adenovirus suppressed TNF-alpha induced MCP-1 mRNA levels and MCP-1 protein secretion ... Expression of N17Rac1 inhibited TNF-alpha induced MCP-1 and NF-kappaB transcriptional activity ... These data suggest that ROS such as superoxide and H ( 2 ) O ( 2 ) derived from Rac1 activated NADPH oxidase mediate TNF-alpha induced MCP-1 expression in endothelial cells
Hu et al., J Immunol 2008 (MAP Kinase Signaling System) : IFN-gamma altered monocyte responses to CCL2 by modulating the activity of Pyk2, JNK, and the GTPases Rac and Cdc42, and inhibiting CCL2 induced activation of the downstream p21 activated kinase that regulates the cytoskeleton and cell polarization
Schreiber et al., Innate Immun 2013 : Furthermore, inhibiting Rac in HRV exposed macrophages attenuated activation of the stress kinase p38 and release of the pro-inflammatory cytokine CCL2 , but inhibiting Rac did not affect release of the pro-inflammatory cytokine CCL5