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CYBB — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases)
  Rinckel et al., Biochem Biophys Res Commun 1999*
  Evidence: Upon stimulation, a functional NADPH oxidase is assembled when the cytosolic proteins, Rac, p67phox, p47phox, and possibly p40phox, associate with the gp91phox and p22phox transmembrane proteins.
• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases, Activity)
  
  Evidence: PKC is known to induce cellular reactive oxygen species (ROS) and PKC-dependent activation of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH oxidase has recently been shown to be responsible, in part, for increased oxidative stress in diabetes.
• KEGG Osteoclast differentiation: RAC1 → CYBA/CYBB/NCF1/NCF2/NCF4/NOX1/NOX3 (protein-protein, activation)
  
• KEGG Leukocyte transendothelial migration: RAC1 → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 (protein-protein, activation)
  
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) (modification, collaborate)
  Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• Reactome Reaction: CYBB → RAC1 (indirect_complex) Ushio-Fukai et al., Circ Res 2002*
• Reactome Reaction: CYBB → RAC1 (reaction) Ushio-Fukai et al., Circ Res 2002*
• WikiPathways Microglia Pathogen Phagocytosis Pathway: RAC1/RAC2/RAC3 → NCF1/NCF4/NCF2/RAC1/RAC2/RAC3/CYBB/CYBA (activation)
  
• WikiPathways Microglia Pathogen Phagocytosis Pathway: CYBB → NCF1/NCF4/NCF2/RAC1/RAC2/RAC3/CYBB/CYBA (mim-conversion)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: Complex of CYBB-CYBA-TNFRSF1A-RFK-NOX1-RAC1 (anti bait coimmunoprecipitation) Yazdanpanah et al., Nature 2009
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Grizot et al., Biochemistry 2001*, Li et al., J Biol Chem 2002, Leto et al., Proc Natl Acad Sci U S A 1994, Sathyamoorthy et al., J Biol Chem 1997*
• IRef Hprd Interaction: CYBB — RAC1 (in vivo) Li et al., J Biol Chem 2002

Text-mined interactions from Literome

Takeya et al., Methods Enzymol 2006 : Rac , albeit probably dispensable to the Nox3 activity, plays an essential role in activation of gp91phox
Miyano et al., Biochem J 2009 : Rac1 and Rac2, which belong to the Rho subfamily of Ras related GTPases, play an essential role in activation of gp91phox/Nox2 ( cytochrome b-245, beta polypeptide ; also known as Cybb ), the catalytic core of the superoxide producing NADPH oxidase in phagocytes
Zhou et al., Free Radic Biol Med 2012 : Rac1 , a Rho-like small GTPase, enhanced p67(phox)-gp91(phox) interaction ; Rac1 inhibition decreased rotenone elicited superoxide release