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IL6 — TNFRSF1A
Text-mined interactions from Literome
Kulms et al., J Biol Chem 2000
:
Transfection with a dominant negative mutant of the signaling protein TRAF-2 reduced IL-6 release upon exposure to UV, indicating that UV-induced
IL-6 release is
mediated by activation of the
tumor necrosis factor receptor-1
Amrani et al., Mol Pharmacol 2001
:
Tumor necrosis factor receptor
(TNFR) 1 , but not TNFR2,
mediates tumor necrosis factor-alpha induced
interleukin-6 and RANTES in human airway smooth muscle cells : role of p38 and p42/44 mitogen activated protein kinases ... Using receptor-specific blocking antibodies, we found that
TNFR1 primarily
regulates TNF alpha induced
IL-6 and RANTES secretion and activation of p38 and p42/44 MAPK pathways
Kunisch et al., Ann Rheum Dis 2007
(Arthritis, Rheumatoid...) :
Reduction of proliferation and induction of
IL6 , IL8 and MMP-1 were solely
mediated by
TNF-R1 , whereas PGE ( 2 ) and MMP-3 secretion was mediated by both TNF-Rs
Claro et al., Microbiology 2013
:
Silencing
TNFR-1 in osteoblasts or disruption of the spa gene in S. aureus
prevented both NF?B activation and
IL-6 release
Butler et al., Eur Cytokine Netw 1994
(Arthritis, Rheumatoid) :
Both
p55 and p75 TNF receptors on dermal and gingival fibroblasts were also
involved in TNF-alpha mediated DNA synthesis and
IL-6 , IL-8 and PGE2 release, although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types