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CDKN1A — CHKA
Text-mined interactions from Literome
Gottifredi et al., Mol Cell Biol 2001
:
Repression of
CHK1 by p53
requires p21 , since p21 alone is sufficient for this to occur and cells lacking p21 can not downregulate CHK1
Buscemi et al., Oncogene 2004
:
We show that doses of gamma-radiation ( IR ) as low as 0.25 Gy, which generate vast numbers of SSBs but only a few DSBs per cell ( < 8 ), promptly activate ATM kinase and induce the phosphorylation of the ATM substrates p53-Ser15, Nbs1-Ser343 and Chk2-Thr68. The full activation of Chk2 kinase, however, is triggered by treatments inflicting > 19 DSBs per cell ( e.g. 1 Gy ), which cause Chk2 autophosphorylation on Thr387,
Chk2 dependent accumulation of
p21waf1 and checkpoint arrest in the S phase
Visanji et al., J Nutr 2004
:
Both benzyl and phenethyl isothiocyanate increased DNA strand breakage, increased phosphorylation of the G(2)/M checkpoint enforcer
Chk2 , and
induced p21 expression
Aliouat-Denis et al., Mol Cancer Res 2005
(Breast Neoplasms...) :
These results revealed a p53 independent
role for
Chk2 in
p21 induction and senescence that may contribute to tumor suppression and genotoxic treatment outcome
Colton et al., J Biol Chem 2006
:
The results obtained from the Western blot experiment showed that NER defects resulted in enhanced
CHK1 phosphorylation and
p21 induction after cisplatin treatment
Cao et al., Toxicol Appl Pharmacol 2007
(Ataxia Telangiectasia) :
Cadmium produced a very unusual pattern of toxicity in human fibroblasts, inhibiting DNA replication and inducing p53 dependent growth arrest but without induction of
p21 ( Cip1/Waf1 ) or
activation of
Chk1
Nguyen et al., Cell cycle (Georgetown, Tex.) 2011
:
These responses are coupled with G2/G1 checkpoint effectors
p21 ( CDKN1A ) upregulation, and
Chk1 and Chk2
activation