◀ Back to JAK3
IL7R — JAK3
Pathways - manually collected, often from reviews:
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
PYK2 (PTK2B)
(modification, activates)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
BCL-2 (BCL2)
(modification, activates)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
FYN
(modification, activates)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
IL-7/IL-7Ra/IL-2R-gamma/JAK1 complex (ITGA2B-Il7r-IL2RG-JAK1)
(modification, collaborate)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1 complex (ITGA2B-Il7r-IL2RG-JAK1)
→
JAK3
(modification, collaborate)
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
LCK
(modification, activates)
-
KEGG Jak-STAT signaling pathway:
CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR
→
JAK1/JAK2/JAK3/TYK2
(protein-protein, phosphorylation)
-
Reactome Reaction:
IL7R
→
JAK3
(reaction)
Kondo et al., Science 1994*, Noguchi et al., Science 1993*
-
Reactome Reaction:
IL7R
→
JAK3
(indirect_complex)
Kondo et al., Science 1994*, Noguchi et al., Science 1993*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mandal et al., Int Immunopharmacol 2006
(Carcinoma, Ehrlich Tumor...) :
A search for the underlying mechanism revealed EAC induced
IL-7Ralpha down-regulation,
inhibition of
JAK3 and STAT5 phosphorylation, and decrease in Bcl-2/Bax ratio in thymocytes that finally led to thymocyte apoptosis in one hand and T cell maturation block on the other
Faller et al., Int Immunol 2009
(HIV Infections) :
However, where 0.5 microg ml(-1) of Tat has no effect on CD127 expression and 200 pg ml(-1) of IL-7 decreases CD127 by only 14 %, these two together at these same concentrations induce a 35 % reduction in CD127 expression after 24 h. Inhibition of
Janus kinase ( JAK ) completely
blocks IL-7 's ability to down-regulate
CD127 on the surface of CD8 T cells and also abolishes synergy with Tat
Henriques et al., Blood 2010
:
IL-7 induces rapid clathrin mediated internalization and
JAK3 dependent degradation of
IL-7Ralpha in T cells