◀ Back to STAT3
STAT3 — TYK2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
STAT3
→
TYK2
(increases, TYK2 Activity, STAT3 Activity)
Evidence: the IFN-a receptor lacks intrinsic kinase activity and instead uses Jak1 and Tyk2 to initiate signal transduction. Ligandinduced dimerization of IFNAR-1 and IFNAR-2 allows juxtaposition and activation of the associated Jaks, leading to activation of downstream signaling pathways (e.g., STAT1, -2, and -3)
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OpenBEL Selventa BEL large corpus:
STAT3
→
TYK2
(increases, TYK2 Activity)
Novak et al., Blood 1995*
Evidence: The activation of the STAT proteins in BMM is accompanied by tyrosine phosphorylation of Tyk2. In fibroblasts, the activation of the STAT proteins is accompanied by tyrosine phosphorylation of Tyk2 and JAK1.
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BioCarta stat3 signaling pathway:
Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2)
→
STAT3
(modification, activates)
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BioCarta il22 soluble receptor signaling pathway:
STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B)
→
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
(modification, collaborate)
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BioCarta il22 soluble receptor signaling pathway:
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
→
STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B)
(modification, activates)
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KEGG Jak-STAT signaling pathway:
JAK1/JAK2/JAK3/TYK2
→
STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6
(protein-protein, phosphorylation)
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KEGG Toxoplasmosis:
JAK1/TYK2
→
STAT3
(protein-protein, activation)
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NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
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NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT3 (dimer)-active complex (STAT3)
(modification, activates)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
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NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
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NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
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NCI Pathway Database IL27-mediated signaling events:
STAT3 (STAT3)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Bright et al., J Immunol 1999
(Encephalomyelitis, Autoimmune, Experimental) :
Inhibition of either Jak-2 or
Tyk-2 leads to a decrease in the IL-12 induced tyrosine phosphorylation of
Stat3 , but not of Stat4, protein
Rani et al., J Biol Chem 1999
:
Catalytically active
TYK2 is
essential for interferon-beta mediated phosphorylation of
STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase ... Our results indicate that catalytically active
TYK2 is
required for IFN-beta mediated tyrosine phosphorylation of
STAT3 and IFNAR-1 in intact cells
Lukashova et al., J Biol Chem 2001
:
Activation of
Tyk2 was
followed by a time dependent 2-4-fold increase in the level of tyrosine phosphorylation of signal transducers and activators of transcription 1 ( STAT1 ), STAT2, and
STAT3 and a sustained 2.5-fold increase in STAT5 tyrosine phosphorylation
Liu et al., Am J Respir Cell Mol Biol 2002
(Lung Neoplasms) :
NRG-1 induced a rapid and transient increase in tyrosine phosphorylation of
TYK2 and JAK3, but not JAK1 or JAK2, and
induced STAT3 and STAT5 tyrosine phosphorylation
Gamero et al., J Biol Chem 2006
:
These results demonstrate an important role of
Tyk2 mediated tyrosine phosphorylation of
Stat3 in the ability of IFNbeta to stimulate apoptosis of primary pro-B cells
Potla et al., Mol Cell Biol 2006
:
Consistent with the
role of
Tyk2 in the regulation of tyrosine phosphorylation of
Stat3 , expression of a constitutively active Stat3 can restore the mitochondrial respiration in Tyk2-null cells treated with IFN-beta
Shide et al., Leuk Res 2007
(Myeloproliferative Disorders...) :
V678F
Tyk2 augmented the transcriptional activity of
Stat3 and Stat5
Li et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis...) :
JAK1/TYK2 leads to
STAT3 activation, Akt dependent NF-kappaB activation, and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase p38
Paradowska-Gorycka et al., Scand J Immunol 2010
(Arthritis, Rheumatoid...) :
IL-23 binding to an IL-23 receptor expressed on dendritic cells, macrophages and monocytes triggers the activation of Jak2 and
Tyk2 , which in turn phosphorylates STAT1, STAT3, STAT4 and STAT5 as well as
induce formation of
STAT3-STAT4 heterodimers
Bhattacharjee et al., Free Radic Biol Med 2013
:
We further show that Jak2 is upstream of
Stat3 activation and
Tyk2 controls Stat1 and Stat6 activation in response to IL-13 stimulation
Gatsios et al., J Biol Chem 1998
:
In this study, we demonstrate that in different cell lines a particular stress, namely hyperosmolarity, results in tyrosine phosphorylation of the Janus kinases Jak1, Jak2, and
Tyk2 and in the
activation of STAT1 and/or
STAT3
Ahn et al., J Immunol 1998
:
While IL-12 is known to activate JAK2 and
TYK2 and
induce the phosphorylation of STAT4 and
STAT3 , little is known regarding how the activation of these signaling molecules is related to the biologic effects of IL-12