Gene interactions and pathways from curated databases and text-mining

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STAT3 — TYK2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bright et al., J Immunol 1999 (Encephalomyelitis, Autoimmune, Experimental) : Inhibition of either Jak-2 or Tyk-2 leads to a decrease in the IL-12 induced tyrosine phosphorylation of Stat3 , but not of Stat4, protein
Rani et al., J Biol Chem 1999 : Catalytically active TYK2 is essential for interferon-beta mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase ... Our results indicate that catalytically active TYK2 is required for IFN-beta mediated tyrosine phosphorylation of STAT3 and IFNAR-1 in intact cells
Lukashova et al., J Biol Chem 2001 : Activation of Tyk2 was followed by a time dependent 2-4-fold increase in the level of tyrosine phosphorylation of signal transducers and activators of transcription 1 ( STAT1 ), STAT2, and STAT3 and a sustained 2.5-fold increase in STAT5 tyrosine phosphorylation
Liu et al., Am J Respir Cell Mol Biol 2002 (Lung Neoplasms) : NRG-1 induced a rapid and transient increase in tyrosine phosphorylation of TYK2 and JAK3, but not JAK1 or JAK2, and induced STAT3 and STAT5 tyrosine phosphorylation
Gamero et al., J Biol Chem 2006 : These results demonstrate an important role of Tyk2 mediated tyrosine phosphorylation of Stat3 in the ability of IFNbeta to stimulate apoptosis of primary pro-B cells
Potla et al., Mol Cell Biol 2006 : Consistent with the role of Tyk2 in the regulation of tyrosine phosphorylation of Stat3 , expression of a constitutively active Stat3 can restore the mitochondrial respiration in Tyk2-null cells treated with IFN-beta
Shide et al., Leuk Res 2007 (Myeloproliferative Disorders...) : V678F Tyk2 augmented the transcriptional activity of Stat3 and Stat5
Li et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : JAK1/TYK2 leads to STAT3 activation, Akt dependent NF-kappaB activation, and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase p38
Paradowska-Gorycka et al., Scand J Immunol 2010 (Arthritis, Rheumatoid...) : IL-23 binding to an IL-23 receptor expressed on dendritic cells, macrophages and monocytes triggers the activation of Jak2 and Tyk2 , which in turn phosphorylates STAT1, STAT3, STAT4 and STAT5 as well as induce formation of STAT3-STAT4 heterodimers
Bhattacharjee et al., Free Radic Biol Med 2013 : We further show that Jak2 is upstream of Stat3 activation and Tyk2 controls Stat1 and Stat6 activation in response to IL-13 stimulation
Gatsios et al., J Biol Chem 1998 : In this study, we demonstrate that in different cell lines a particular stress, namely hyperosmolarity, results in tyrosine phosphorylation of the Janus kinases Jak1, Jak2, and Tyk2 and in the activation of STAT1 and/or STAT3
Ahn et al., J Immunol 1998 : While IL-12 is known to activate JAK2 and TYK2 and induce the phosphorylation of STAT4 and STAT3 , little is known regarding how the activation of these signaling molecules is related to the biologic effects of IL-12