Gene interactions and pathways from curated databases and text-mining

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JUN — SMAD3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Dennler et al., J Biol Chem 2000 : However, c-Jun does not inhibit Smad3 binding to DNA in vitro
Qing et al., J Biol Chem 2000 : Mutational analyses of the c-Jun protein and the AP-1 binding site in the promoter revealed that the interaction of c-Jun with DNA is necessary for transcriptional activation by TGF-beta and Smad3
Verrecchia et al., Oncogene 2001 : Finally, we have determined that off-DNA interactions between Smad3 and both c-Jun and JunB result in the reduction of Smad3/DNA interactions
Feinberg et al., Circ Res 2004 (Hyperplasia...) : We demonstrate that the inhibitory effect of Smad3 occurs via a novel antagonistic effect of Smad3 on AP-1 DNA-protein binding and activity
Zhang et al., Am J Pathol 2006 : Furthermore, Smad3 blockade specifically inhibited activation of the transcription factor AP-1 by TGF-beta1, whereas PD98059 prevented TGF-beta1 dependent nuclear factor-kappaB activation
Sundqvist et al., Oncogene 2013 (Breast Neoplasms...) : Finally, chromatin immunoprecipitations showed that c-Jun , JunB and Fra1, but not c-Fos, are required for TGFß induced binding of Smad2/3 to the mmp-10 and pai-1 promoters
Mucsi et al., Biochem Biophys Res Commun 1997 : Activation of the PAI-1 promoter by TGF-beta or prostaglandin F2 alpha, and transactivation by c-Jun or JunB were not inhibited by dominant negative Smad3 , supporting the specificity of this mutant