Gene interactions and pathways from curated databases and text-mining

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BSG — EGF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: BSG → EGF (decreases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Menashi et al., Cancer Res 2003 (Breast Neoplasms) : AR and epidermal growth factor , therefore, regulate EMMPRIN and its MMP mediated expression, identifying EGFR signaling as critical to this regulation
Gabison et al., Am J Pathol 2005 (Corneal Ulcer) : These findings, and the up-regulation of EMMPRIN by epidermal growth factor and transforming growth factor-beta, demonstrate a role for EMMPRIN in wound healing and suggest that sustained local up-regulation of EMMPRIN and MMPs in chronic situations in which healing is delayed may lead to excessive matrix degradation and corneal melts