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PPARA — TFAP2A

Text-mined interactions from Literome

Case et al., Bone 2013 : To assess whether a reduction in PPAR? expression was necessary for anti-adipogenic action, PPAR?2 was overexpressed : both mechanical strain and GSK3ß inhibition prevented expression of aP2 and adiponectin proteins despite abundant PPAR?2 and its ligand
Mehta et al., Mol Cell Biochem 2013 (Mammary Neoplasms, Experimental...) : The results were as follows : ( a ) the incidence of MAL development was significantly inhibited by GW 7845 and GW 9662 ; ( b ) GW9662 but not GW7845, in the presence of estradiol, induced ER and PR expression in mammary glands and functional ERa in MAL ; ( c ) while GW9662 inhibited expression of adipsin and ap2 , GW 7845 enhanced expression of these PPAR?-response genes ; and ( d ) Tamoxifen caused significant inhibition of GW9662 treated MAL, suggesting that GW9662 sensitizes MAL to antiestrogen treatment, presumably through rendering functional ERa and induction of PR
Honda et al., Am J Physiol Cell Physiol 2013 : The upregulation of aP2 and CCAAT/enhancer binding protein (C/EBP)-ß during adipocyte differentiation was also enhanced in the PDZRN3 depleted cells, as was the induction of peroxisome proliferator activated receptor-? ( PPAR? ), an upstream regulator of aP2 and C/EBPa, at both the mRNA and protein levels