Gene interactions and pathways from curated databases and text-mining

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HCLS1 — JUN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ward et al., Eur J Neurosci 2000 (Nerve Degeneration) : These results suggest that the expected activation of the JNK pathway by p75NGFR , as well as the expected relationship between SEK1 and downstream activation of c-Jun do not occur in the mammalian forebrain
Wang et al., J Mol Neurosci 2000 (MAP Kinase Signaling System) : Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities
Bhakar et al., J Neurosci 2003 (MAP Kinase Signaling System) : In this study, we show that overexpression of p75NTR in primary cortical neurons, in pheochromocytoma cell line ( PC12 ) cells, and in glioma cells results in activation of Jun kinase (JNK) , accumulation of cytochrome c within the cytosol, and activation of caspases 9, 6, and 3