◀ Back to PLCG1
BLNK — PLCG1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Class I PI3K signaling events:
None
→
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, collaborate)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, activates)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
→
None
(modification, activates)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
PLC-gamma family (PLCG1/PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
PLC-gamma family (PLCG1/PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
Reactome Reaction:
PLCG1
→
BLNK
(indirect_complex)
Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
DeBell et al., Mol Cell Biol 1999
:
Tyrosine phosphorylation did not require the SH2 ( C ) or SH3 domains but depended exclusively on a functional SH2 ( N ) domain, which
mediated the association of
PLCgamma1 with the adapter protein,
BLNK
Tzeng et al., Protein Sci 2000
(Agammaglobulinemia) :
Recently, the
B-cell linker protein (BLNK) was found to interact with the SH2 domain of Btk, and this association is
required for the activation of
phospholipase C-gamma