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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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GLI1 — WNT16

Pathways - manually collected, often from reviews:

  • KEGG Hedgehog signaling pathway: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)
  • KEGG Pathways in cancer: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)
  • KEGG Basal cell carcinoma: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)

Text-mined interactions from Literome

Akiyoshi et al., Gut 2006 (Colonic Neoplasms) : To investigate whether expression of Gli1 , a transactivator of Hh signalling, can suppress Wnt signalling and inhibit proliferation of human colorectal cancer cells
Yanai et al., Cancer Lett 2008 (Stomach Neoplasms) : When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear beta-catenin accumulation and proliferation of AGS cells
Nakamura et al., J Biol Chem 2013 (Wnt Signaling Pathway) : WNT induces GLI1 expression in a SULF2- and ß-CATENIN dependent manner