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NOTCH4 — SMAD3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fu et al., J Biol Chem 2009
:
In contrast,
Notch increases SMAD3 mRNA expression and protein half-life and
regulates the expression of
TGFbeta/Smad3 target genes in a gene-specific manner ... Inhibition of
Notch in the cardiac cushion of mouse embryonic hearts
reduces Smad3 expression ... This is the first evidence that
Notch activation
affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways
Grabias et al., American journal of physiology. Renal physiology 2013
(Fibrosis...) :
These divergent patterns of SMAD3 activation are attributed to varying levels of
Notch4 dependent
phospho-SMAD3 degradation ... Depletion of
Notch4 in shear stimulated PTECs eventually increases the levels of active TGF-ß1 protein by approximately fivefold,
recovers stable
SMAD phosphorylation and ubiquitinated SMAD species, and attenuates collagen accumulation