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ATF4 — HSPA5

Text-mined interactions from Literome

Luo et al., J Biol Chem 2003 : Induction of Grp78/BiP by translational block : activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements ... We report here that ATF4 , a transcription factor whose translation is up-regulated by the PERK-eIF2alpha pathway, can activate the Grp78 promoter independent of the ERSE
Tsutsumi et al., Oncogene 2006 (Carcinoma...) : Suppression of ATF4 expression by small interfering RNA ( siRNA ) partially inhibited the celecoxib dependent upregulation of GRP78
Mamady et al., Mol Cell Biochem 2006 : Electrophoretic mobility shift and supershift assays showed that the activating transcription factor , ATF4, binds to the promoter region of the grp78 gene in ground squirrel brain and may be responsible for grp78 up-regulation during hibernation
Hengstermann et al., Free Radic Biol Med 2008 : Activation of PERK and PERK dependent signaling by aqueous extracts of CS was demonstrated by ( i ) the inhibition of protein synthesis, ( ii ) the phosphorylation of PERK and its substrate eIF2alpha, ( iii ) the activation of ATF4 , and ( iv ) the expression of ATF4 dependent target genes chop, gadd34, BiP , and atf3