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EIF4E — MKNK2

Pathways - manually collected, often from reviews:

• KEGG Insulin signaling pathway: MKNK1/MKNK2 → EIF4E/EIF4E1B/EIF4E2 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: MKNK2 — EIF4E (in vivo) Scheper et al., Mol Cell Biol 2003*, Waskiewicz et al., EMBO J 1997
• IRef Hprd Interaction: MKNK2 — EIF4E (in vitro) Scheper et al., Mol Cell Biol 2003*, Waskiewicz et al., EMBO J 1997
• IRef Innatedb Interaction: EIF4E — MKNK2 (unknown, -) Scheper et al., Mol Cell Biol 2003*

Text-mined interactions from Literome

Scheper et al., Mol Cell Biol 2001 : These compounds did not abolish phosphorylation of eIF4E, implying that Mnk2 may mediate phosphorylation of eIF4E in Swiss 3T3 cells
Scheper et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Expression of Mnk2b in mammalian cells leads to increased phosphorylation of eIF4E , showing that it acts as an eIF4E kinase in vivo
Ueda et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : Analysis of embryonic fibroblasts from single KO mice revealed that Mnk1 is responsible for the inducible phosphorylation of eIF4E in response to MAP kinase activation, whereas Mnk2 mainly contributes to eIF4E 's basal, constitutive phosphorylation ... Thus, Mnk1 and Mnk2 are exclusive eIF4E kinases both in cultured fibroblasts and adult tissues, and they regulate inducible and constitutive eIF4E phosphorylation, respectively