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CASP10 — CSF2
Text-mined interactions from Literome
Watson et al., FEBS Lett 1999
:
LPS,
GM-CSF and increased glutathione stabilised the mitochondria and
inhibited caspase 3
Ottonello et al., J Leukoc Biol 2002
(Granulomatous Disease, Chronic) :
Accordingly, the spontaneous activity of
caspase-3 was
inhibited by
GM-CSF , IL-6, and IL-15
Hsu et al., J Leukoc Biol 2002
:
Annexin V staining and MTT assays reveal that PS-G is able to inhibit spontaneous and Fas induced neutrophil apoptosis, and this effect of PS-G is enhanced by the presence of zVAD ( a
caspase inhibitor ) and
GM-CSF
Zeigler et al., J Biol Chem 2003
:
The caspase-3-selective inhibitor DEVD-fluoromethyl ketone reversed DNA fragmentation events, and the caspase-9 inhibitor LEHD-fluoromethyl ketone reversed
caspase-3 activity in monocytes treated with PAPA or DEA NONOate in the
presence of macrophage
colony stimulating factor
Faderl et al., Blood 2003
(Acute Disease...) :
Concurrently,
GM-CSF stimulated expression of SOCS-2 and -3 and of procaspases 2 and 3 and
induced caspase 3 activation, poly ( ADP [ adenosine 5'-diphosphate ] -ribose ) polymerase ( PARP ) cleavage, and apoptotic cell death ... The Janus kinase ( Jak ) -Stat inhibitor AG490 abrogated
GM-CSF induced expression of procaspase 3 and activation of
caspase 3
Murata-Ohsawa et al., Int J Mol Med 2004
(MAP Kinase Signaling System) :
GM-CSF stimulation
induced the phosphorylation of ERK1/2 and STAT5 and the cleavage of
caspase-8 , which were not affected by Delta-1 incubation, either
Scheller et al., J Neural Transm Suppl 2006
:
In previous studies we have reported that
caspase inhibitors
induce expression of various proinflammatory cytokines in CD95 stimulated primary T cells, such as TNF-alpha, IFN-gamma and
GM-CSF
Yamashita et al., Blood 1999
:
Granulocyte-macrophage
colony stimulating factor inhibited TNF-alpha induced
caspase activation and apoptosis, while reversing the diminution in superoxide release