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FAS — YY1
Text-mined interactions from Literome
Vega et al., J Immunol 2005
(Lymphoma, Non-Hodgkin) :
Inhibition of
YY1 activity by either rituximab or the NO donor DETANONOate or after transfection with YY1 small interfering RNA
resulted in up-regulation of
Fas expression and sensitization to CH-11 induced apoptosis
Vega et al., Oncogene 2005
(Burkitt Lymphoma...) :
Inhibition of
YY1 resulted in the upregulation of
Fas expression and sensitization of the tumor cells to CH-11 induced apoptosis ... The
involvement of NF-kappaB and
YY1 in the regulation of
Fas expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor ( ER ) mutant ) and by silencing YY1 with YY1 siRNA, respectively
Hongo et al., Biochem Biophys Res Commun 2005
(Prostatic Neoplasms) :
Previous findings demonstrated that the transcription repressor
Yin Yang 1 (YY1) , which is inhibited by NO, negatively
regulates Fas transcription [ H.J. Garban, B. Bonavida, Nitric oxide inhibits the transcription repressor Yin-Yang 1 binding activity at the silencer region of the Fas promoter : a pivotal role for nitric oxide in the upregulation of Fas gene expression in human tumor cells, J. Immunol. 167 ( 2001 ) 75-81 ] ... The direct
role of
YY1 in the negative regulation of
Fas expression was demonstrated by transfection of cells with siRNA YY1
Huerta-Yepez et al., Clin Immunol 2006
(Adenocarcinoma...) :
We have reported that
Fas expression and sensitivity to FasL is negatively
regulated by the transcription repressor factor
Yin Yang 1 (YY1)