Lai et al., J Cell Physiol 2005
(MAP Kinase Signaling System) :
Stimulation of the PTH1R or blocking of beta1-integrin resulted in inhibition of ERK1/2 and p38 MAPK and decreased levels of Ihh mRNA
Sneddon et al., American journal of physiology. Renal physiology 2007
:
Pertussis toxin inhibited PTH stimulated ERK1/2 by mutated and truncated PTH1Rs and abolished ERK1/2 activation by wild-type PTH1R ... We conclude that ERK phosphorylation in distal kidney cells by PTH requires PTH1R activation of G ( i ), which leads to stimulation of metalloprotease mediated cleavage of HB-EGF and transactivation of the EGFR and is regulated by EBP50
Datta et al., Cell Signal 2010
:
Distinct roles for mitogen activated protein kinase phosphatase-1 ( MKP-1 ) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation
Alonso et al., J Bone Miner Res 2011
:
Signaling and activation of cAMP and ERK by de14-PTHR was decreased significantly compared with PTHR