Schulze-Bergkamen et al., Hepatology 2004
:
Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95 mediated apoptosis via Akt ... HGF transcriptionally induced the expression of the anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) ... Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF
Fleischer et al., Int J Oncol 2006
(Carcinoma, Hepatocellular...) :
Furthermore, the hepatocyte growth factor and epidermal growth factor induced Mcl-1 expression in an Akt- and ERK dependent manner